Early detection of influenza A and B infection in infants and children using conventional and fluorescence-based rapid testing.
Identifieur interne : 000248 ( Main/Exploration ); précédent : 000247; suivant : 000249Early detection of influenza A and B infection in infants and children using conventional and fluorescence-based rapid testing.
Auteurs : Barbara Rath [Allemagne] ; Franziska Tief ; Patrick Obermeier ; Ewelina Tuerk ; Katharina Karsch ; Susann Muehlhans ; Eleni Adamou ; Susanne Duwe ; Brunhilde SchweigerSource :
- Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology [ 1873-5967 ] ; 2012.
Descripteurs français
- KwdFr :
- Adolescent, Berlin, Diagnostic précoce, Enfant, Enfant d'âge préscolaire, Femelle, Grippe humaine (diagnostic), Humains, Mâle, Nourrisson, Sensibilité et spécificité, Systèmes automatisés lit malade, Techniques de laboratoire clinique (), Virologie (), Virus de la grippe A (isolement et purification), Virus influenza B (isolement et purification).
- MESH :
- diagnostic : Grippe humaine.
- isolement et purification : Virus de la grippe A, Virus influenza B.
- Adolescent, Berlin, Diagnostic précoce, Enfant, Enfant d'âge préscolaire, Femelle, Humains, Mâle, Nourrisson, Sensibilité et spécificité, Systèmes automatisés lit malade, Techniques de laboratoire clinique, Virologie.
English descriptors
- KwdEn :
- Adolescent, Berlin, Child, Child, Preschool, Clinical Laboratory Techniques (methods), Early Diagnosis, Female, Humans, Infant, Influenza A virus (isolation & purification), Influenza B virus (isolation & purification), Influenza, Human (diagnosis), Male, Point-of-Care Systems, Sensitivity and Specificity, Virology (methods).
- MESH :
- geographic : Berlin.
- diagnosis : Influenza, Human.
- isolation & purification : Influenza A virus, Influenza B virus.
- methods : Clinical Laboratory Techniques, Virology.
- Adolescent, Child, Child, Preschool, Early Diagnosis, Female, Humans, Infant, Male, Point-of-Care Systems, Sensitivity and Specificity.
Abstract
BACKGROUND
The appropriate management of infants and children with influenza depends on the accurate and timely diagnosis, ideally at the point of care (POC).
OBJECTIVES
To evaluate the use of simultaneous RSV/influenza rapid testing with QuickVue™ test strips as well as (the use of) novel, fluorescence-based, rapid influenza antigen testing (SOFIA™) in infants and children with influenza-like illness (ILI).
STUDY DESIGN
The Study was conducted in a real-time surveillance program at the Charité Department of Pediatrics in collaboration with the National Reference Centre for Influenza at the Robert Koch Institute (RKI) in Berlin, Germany (Charité Influenza-Like Disease=ChILD Cohort).
RESULTS
During the 2010/2011 influenza season, 395 infants and children were simultaneously tested using QuickVue™ FluA&B and RSV10 rapid tests at POC compared to independent RT-PCR. Sensitivities were 62.7/67.8% for Influenza/RSV overall, but highest in infants <1 year with 76.0/76.2%. The evaluation of the fluorescence-based rapid test SOFIA™ with frozen laboratory samples (derived from the 2008/2009 and 2010/2011 national surveillance) yielded sensitivities of 97.7/86.7/86.7/81.7% for influenza A(H1N1)pdm09/A(H3N2)/B-Victoria/B-Yamagata in samples with CT values <34, and 80.2/79.8/67.5/62.5% for all CT values combined. The same method used at POC with 649 consecutive ChILD patients in 2011-2012 yielded sensitivity/specificity/PPV/NPV values of 78.9/99.7/96.6/97.3%. Again, sensitivities were highest in infants (85.7%) and small children <2 years (88%).
CONCLUSIONS
Fluorescence-based rapid antigen testing provides a highly sensitive and specific tool for POC diagnostics of acute influenza in the paediatric age group, especially in infants and small children <2 years, when viral loads are at their peak and treatment decisions are imminent.
DOI: 10.1016/j.jcv.2012.08.002
PubMed: 22921515
Affiliations:
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Barbara.Rath@gmail.com</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Paediatrics, Division of Pneumonology-Immunology, Charité University Medical Centre, Augustenburger Platz 1, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Tief, Franziska" sort="Tief, Franziska" uniqKey="Tief F" first="Franziska" last="Tief">Franziska Tief</name></author><author><name sortKey="Obermeier, Patrick" sort="Obermeier, Patrick" uniqKey="Obermeier P" first="Patrick" last="Obermeier">Patrick Obermeier</name></author><author><name sortKey="Tuerk, Ewelina" sort="Tuerk, Ewelina" uniqKey="Tuerk E" first="Ewelina" last="Tuerk">Ewelina Tuerk</name></author><author><name sortKey="Karsch, Katharina" sort="Karsch, Katharina" uniqKey="Karsch K" first="Katharina" last="Karsch">Katharina Karsch</name></author><author><name sortKey="Muehlhans, Susann" sort="Muehlhans, Susann" uniqKey="Muehlhans S" first="Susann" last="Muehlhans">Susann Muehlhans</name></author><author><name sortKey="Adamou, Eleni" sort="Adamou, Eleni" uniqKey="Adamou E" first="Eleni" last="Adamou">Eleni Adamou</name></author><author><name sortKey="Duwe, Susanne" sort="Duwe, Susanne" uniqKey="Duwe S" first="Susanne" last="Duwe">Susanne Duwe</name></author><author><name sortKey="Schweiger, Brunhilde" sort="Schweiger, Brunhilde" uniqKey="Schweiger B" first="Brunhilde" last="Schweiger">Brunhilde Schweiger</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2012">2012</date><idno type="RBID">pubmed:22921515</idno><idno type="pmid">22921515</idno><idno type="doi">10.1016/j.jcv.2012.08.002</idno><idno type="wicri:Area/Main/Corpus">000224</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000224</idno><idno type="wicri:Area/Main/Curation">000224</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000224</idno><idno type="wicri:Area/Main/Exploration">000224</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Early detection of influenza A and B infection in infants and children using conventional and fluorescence-based rapid testing.</title><author><name sortKey="Rath, Barbara" sort="Rath, Barbara" uniqKey="Rath B" first="Barbara" last="Rath">Barbara Rath</name><affiliation wicri:level="3"><nlm:affiliation>Department of Paediatrics, Division of Pneumonology-Immunology, Charité University Medical Centre, Augustenburger Platz 1, Berlin, Germany. Barbara.Rath@gmail.com</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Paediatrics, Division of Pneumonology-Immunology, Charité University Medical Centre, Augustenburger Platz 1, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Tief, Franziska" sort="Tief, Franziska" uniqKey="Tief F" first="Franziska" last="Tief">Franziska Tief</name></author><author><name sortKey="Obermeier, Patrick" sort="Obermeier, Patrick" uniqKey="Obermeier P" first="Patrick" last="Obermeier">Patrick Obermeier</name></author><author><name sortKey="Tuerk, Ewelina" sort="Tuerk, Ewelina" uniqKey="Tuerk E" first="Ewelina" last="Tuerk">Ewelina Tuerk</name></author><author><name sortKey="Karsch, Katharina" sort="Karsch, Katharina" uniqKey="Karsch K" first="Katharina" last="Karsch">Katharina Karsch</name></author><author><name sortKey="Muehlhans, Susann" sort="Muehlhans, Susann" uniqKey="Muehlhans S" first="Susann" last="Muehlhans">Susann Muehlhans</name></author><author><name sortKey="Adamou, Eleni" sort="Adamou, Eleni" uniqKey="Adamou E" first="Eleni" last="Adamou">Eleni Adamou</name></author><author><name sortKey="Duwe, Susanne" sort="Duwe, Susanne" uniqKey="Duwe S" first="Susanne" last="Duwe">Susanne Duwe</name></author><author><name sortKey="Schweiger, Brunhilde" sort="Schweiger, Brunhilde" uniqKey="Schweiger B" first="Brunhilde" last="Schweiger">Brunhilde Schweiger</name></author></analytic><series><title level="j">Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology</title><idno type="eISSN">1873-5967</idno><imprint><date when="2012" type="published">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Berlin</term><term>Child</term><term>Child, Preschool</term><term>Clinical Laboratory Techniques (methods)</term><term>Early Diagnosis</term><term>Female</term><term>Humans</term><term>Infant</term><term>Influenza A virus (isolation & purification)</term><term>Influenza B virus (isolation & purification)</term><term>Influenza, Human (diagnosis)</term><term>Male</term><term>Point-of-Care Systems</term><term>Sensitivity and Specificity</term><term>Virology (methods)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent</term><term>Berlin</term><term>Diagnostic précoce</term><term>Enfant</term><term>Enfant d'âge préscolaire</term><term>Femelle</term><term>Grippe humaine (diagnostic)</term><term>Humains</term><term>Mâle</term><term>Nourrisson</term><term>Sensibilité et spécificité</term><term>Systèmes automatisés lit malade</term><term>Techniques de laboratoire clinique ()</term><term>Virologie ()</term><term>Virus de la grippe A (isolement et purification)</term><term>Virus influenza B (isolement et purification)</term></keywords><keywords scheme="MESH" type="geographic" xml:lang="en"><term>Berlin</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Influenza, Human</term></keywords><keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Grippe humaine</term></keywords><keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Influenza A virus</term><term>Influenza B virus</term></keywords><keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Virus de la grippe A</term><term>Virus influenza B</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Clinical Laboratory Techniques</term><term>Virology</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Child</term><term>Child, Preschool</term><term>Early Diagnosis</term><term>Female</term><term>Humans</term><term>Infant</term><term>Male</term><term>Point-of-Care Systems</term><term>Sensitivity and Specificity</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term><term>Berlin</term><term>Diagnostic précoce</term><term>Enfant</term><term>Enfant d'âge préscolaire</term><term>Femelle</term><term>Humains</term><term>Mâle</term><term>Nourrisson</term><term>Sensibilité et spécificité</term><term>Systèmes automatisés lit malade</term><term>Techniques de laboratoire clinique</term><term>Virologie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>BACKGROUND</b></p><p>The appropriate management of infants and children with influenza depends on the accurate and timely diagnosis, ideally at the point of care (POC).</p></div><div type="abstract" xml:lang="en"><p><b>OBJECTIVES</b></p><p>To evaluate the use of simultaneous RSV/influenza rapid testing with QuickVue™ test strips as well as (the use of) novel, fluorescence-based, rapid influenza antigen testing (SOFIA™) in infants and children with influenza-like illness (ILI).</p></div><div type="abstract" xml:lang="en"><p><b>STUDY DESIGN</b></p><p>The Study was conducted in a real-time surveillance program at the Charité Department of Pediatrics in collaboration with the National Reference Centre for Influenza at the Robert Koch Institute (RKI) in Berlin, Germany (Charité Influenza-Like Disease=ChILD Cohort).</p></div><div type="abstract" xml:lang="en"><p><b>RESULTS</b></p><p>During the 2010/2011 influenza season, 395 infants and children were simultaneously tested using QuickVue™ FluA&B and RSV10 rapid tests at POC compared to independent RT-PCR. Sensitivities were 62.7/67.8% for Influenza/RSV overall, but highest in infants <1 year with 76.0/76.2%. The evaluation of the fluorescence-based rapid test SOFIA™ with frozen laboratory samples (derived from the 2008/2009 and 2010/2011 national surveillance) yielded sensitivities of 97.7/86.7/86.7/81.7% for influenza A(H1N1)pdm09/A(H3N2)/B-Victoria/B-Yamagata in samples with CT values <34, and 80.2/79.8/67.5/62.5% for all CT values combined. The same method used at POC with 649 consecutive ChILD patients in 2011-2012 yielded sensitivity/specificity/PPV/NPV values of 78.9/99.7/96.6/97.3%. Again, sensitivities were highest in infants (85.7%) and small children <2 years (88%).</p></div><div type="abstract" xml:lang="en"><p><b>CONCLUSIONS</b></p><p>Fluorescence-based rapid antigen testing provides a highly sensitive and specific tool for POC diagnostics of acute influenza in the paediatric age group, especially in infants and small children <2 years, when viral loads are at their peak and treatment decisions are imminent.</p></div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">22921515</PMID><DateCompleted><Year>2013</Year><Month>03</Month><Day>22</Day></DateCompleted><DateRevised><Year>2019</Year><Month>12</Month><Day>10</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1873-5967</ISSN><JournalIssue CitedMedium="Internet"><Volume>55</Volume><Issue>4</Issue><PubDate><Year>2012</Year><Month>Dec</Month></PubDate></JournalIssue><Title>Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology</Title><ISOAbbreviation>J. Clin. Virol.</ISOAbbreviation></Journal><ArticleTitle>Early detection of influenza A and B infection in infants and children using conventional and fluorescence-based rapid testing.</ArticleTitle><Pagination><MedlinePgn>329-33</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.jcv.2012.08.002</ELocationID><ELocationID EIdType="pii" ValidYN="Y">S1386-6532(12)00287-9</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">The appropriate management of infants and children with influenza depends on the accurate and timely diagnosis, ideally at the point of care (POC).</AbstractText><AbstractText Label="OBJECTIVES" NlmCategory="OBJECTIVE">To evaluate the use of simultaneous RSV/influenza rapid testing with QuickVue™ test strips as well as (the use of) novel, fluorescence-based, rapid influenza antigen testing (SOFIA™) in infants and children with influenza-like illness (ILI).</AbstractText><AbstractText Label="STUDY DESIGN" NlmCategory="METHODS">The Study was conducted in a real-time surveillance program at the Charité Department of Pediatrics in collaboration with the National Reference Centre for Influenza at the Robert Koch Institute (RKI) in Berlin, Germany (Charité Influenza-Like Disease=ChILD Cohort).</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">During the 2010/2011 influenza season, 395 infants and children were simultaneously tested using QuickVue™ FluA&B and RSV10 rapid tests at POC compared to independent RT-PCR. Sensitivities were 62.7/67.8% for Influenza/RSV overall, but highest in infants <1 year with 76.0/76.2%. The evaluation of the fluorescence-based rapid test SOFIA™ with frozen laboratory samples (derived from the 2008/2009 and 2010/2011 national surveillance) yielded sensitivities of 97.7/86.7/86.7/81.7% for influenza A(H1N1)pdm09/A(H3N2)/B-Victoria/B-Yamagata in samples with CT values <34, and 80.2/79.8/67.5/62.5% for all CT values combined. The same method used at POC with 649 consecutive ChILD patients in 2011-2012 yielded sensitivity/specificity/PPV/NPV values of 78.9/99.7/96.6/97.3%. Again, sensitivities were highest in infants (85.7%) and small children <2 years (88%).</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Fluorescence-based rapid antigen testing provides a highly sensitive and specific tool for POC diagnostics of acute influenza in the paediatric age group, especially in infants and small children <2 years, when viral loads are at their peak and treatment decisions are imminent.</AbstractText><CopyrightInformation>Copyright © 2012 Elsevier B.V. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Rath</LastName><ForeName>Barbara</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Department of Paediatrics, Division of Pneumonology-Immunology, Charité University Medical Centre, Augustenburger Platz 1, Berlin, Germany. Barbara.Rath@gmail.com</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tief</LastName><ForeName>Franziska</ForeName><Initials>F</Initials></Author><Author ValidYN="Y"><LastName>Obermeier</LastName><ForeName>Patrick</ForeName><Initials>P</Initials></Author><Author ValidYN="Y"><LastName>Tuerk</LastName><ForeName>Ewelina</ForeName><Initials>E</Initials></Author><Author ValidYN="Y"><LastName>Karsch</LastName><ForeName>Katharina</ForeName><Initials>K</Initials></Author><Author ValidYN="Y"><LastName>Muehlhans</LastName><ForeName>Susann</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Adamou</LastName><ForeName>Eleni</ForeName><Initials>E</Initials></Author><Author ValidYN="Y"><LastName>Duwe</LastName><ForeName>Susanne</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Schweiger</LastName><ForeName>Brunhilde</ForeName><Initials>B</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D003160">Comparative Study</PublicationType><PublicationType UI="D023362">Evaluation Study</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2012</Year><Month>08</Month><Day>24</Day></ArticleDate></Article><MedlineJournalInfo><Country>Netherlands</Country><MedlineTA>J Clin Virol</MedlineTA><NlmUniqueID>9815671</NlmUniqueID><ISSNLinking>1386-6532</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000293" MajorTopicYN="N">Adolescent</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001604" MajorTopicYN="N" Type="Geographic">Berlin</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002648" MajorTopicYN="N">Child</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002675" MajorTopicYN="N">Child, Preschool</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D019411" MajorTopicYN="N">Clinical Laboratory Techniques</DescriptorName><QualifierName UI="Q000379" MajorTopicYN="Y">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D042241" MajorTopicYN="N">Early Diagnosis</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007223" MajorTopicYN="N">Infant</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009980" MajorTopicYN="N">Influenza A virus</DescriptorName><QualifierName UI="Q000302" MajorTopicYN="Y">isolation & purification</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D009981" MajorTopicYN="N">Influenza B virus</DescriptorName><QualifierName UI="Q000302" MajorTopicYN="Y">isolation & purification</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007251" MajorTopicYN="N">Influenza, Human</DescriptorName><QualifierName UI="Q000175" MajorTopicYN="Y">diagnosis</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D019095" MajorTopicYN="Y">Point-of-Care Systems</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012680" MajorTopicYN="N">Sensitivity and Specificity</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014773" MajorTopicYN="N">Virology</DescriptorName><QualifierName UI="Q000379" MajorTopicYN="Y">methods</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2012</Year><Month>07</Month><Day>31</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2012</Year><Month>08</Month><Day>03</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2012</Year><Month>8</Month><Day>28</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2012</Year><Month>8</Month><Day>28</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2013</Year><Month>3</Month><Day>23</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">22921515</ArticleId><ArticleId IdType="pii">S1386-6532(12)00287-9</ArticleId><ArticleId IdType="doi">10.1016/j.jcv.2012.08.002</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Allemagne</li></country><region><li>Berlin</li></region><settlement><li>Berlin</li></settlement></list><tree><noCountry><name sortKey="Adamou, Eleni" sort="Adamou, Eleni" uniqKey="Adamou E" first="Eleni" last="Adamou">Eleni Adamou</name><name sortKey="Duwe, Susanne" sort="Duwe, Susanne" uniqKey="Duwe S" first="Susanne" last="Duwe">Susanne Duwe</name><name sortKey="Karsch, Katharina" sort="Karsch, Katharina" uniqKey="Karsch K" first="Katharina" last="Karsch">Katharina Karsch</name><name sortKey="Muehlhans, Susann" sort="Muehlhans, Susann" uniqKey="Muehlhans S" first="Susann" last="Muehlhans">Susann Muehlhans</name><name sortKey="Obermeier, Patrick" sort="Obermeier, Patrick" uniqKey="Obermeier P" first="Patrick" last="Obermeier">Patrick Obermeier</name><name sortKey="Schweiger, Brunhilde" sort="Schweiger, Brunhilde" uniqKey="Schweiger B" first="Brunhilde" last="Schweiger">Brunhilde Schweiger</name><name sortKey="Tief, Franziska" sort="Tief, Franziska" uniqKey="Tief F" first="Franziska" last="Tief">Franziska Tief</name><name sortKey="Tuerk, Ewelina" sort="Tuerk, Ewelina" uniqKey="Tuerk E" first="Ewelina" last="Tuerk">Ewelina Tuerk</name></noCountry><country name="Allemagne"><region name="Berlin"><name sortKey="Rath, Barbara" sort="Rath, Barbara" uniqKey="Rath B" first="Barbara" last="Rath">Barbara 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